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TPS383 Background: The addition of either docetaxel or abiraterone acetate plus prednisone to androgen deprivation therapy (ADT) improves overall survival (OS) compared with ADT alone in men with mHSPC. It is hypothesized that other androgen receptor (AR)-targeted therapies could be combined with docetaxel for mHSPC. Darolutamide (ODM-201) is an investigational oral AR antagonist with a unique.
Dr. Aras
Darolutamide is a potent androgen-receptor inhibitor that has been associated with increased overall survival among patients with nonmetastatic, castration-resistant prostate cancer. Whether a.
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PURPOSE For patients with metastatic hormone-sensitive prostate cancer, metastatic burden affects outcome. We examined efficacy and safety from the ARASENS trial for subgroups by disease volume and risk. METHODS Patients with metastatic hormone-sensitive prostate cancer were randomly assigned to darolutamide or placebo plus androgen-deprivation therapy and docetaxel. High-volume disease was.
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Christopher Wallis and Zachary Klaassen highlight the New England Journal of Medicine publication on the international, phase 3 ARASENS trial. The primary analysis involved 1306 patients (651 in the darolutamide group and 655 in the placebo group); 86.1% of the patients had disease that was metastatic at the time of the initial diagnosis. At the data cutoff date for the primary analysis.
Ara Informationen, Eigenschaften und Kuriositäten
Trial design: This international, randomized, double-blind, placebo-controlled, phase 3 trial (NCT02799602) is being conducted in 23 countries. 1300 men with newly diagnosed mHSPC will be randomized 1:1 to either 600 mg (2 × 300 mg) darolutamide BID with food, equivalent to a total daily dose of 1200 mg or placebo, both with ADT + docetaxel (6 cycles after randomization), and stratified by.
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The ARAS archive contains about 18,000 art images each accompanied by a scholarly commentary that explores the archetypal content and cultural context of the image. In addition to our image collection, our website offers a rich library of articles on art and symbols and a concordance that allows you to search C.G. Jung's Collected Works by word or topic.
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ASCO GU 2022 ARASENS mHSPC early triplet combination therapy with darolutamide docetaxel and ADT significantly increased overall and improved key secondary endpoints compared with ADT and docetaxel alone with similar rates of treatment emergent adverse events between the two arms, Overall survival ARASENS prostate cancer
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In the ARASENS trial, darolutamide in combination with docetaxel and androgen deprivation therapy (ADT) significantly increased overall survival (OS) compared to placebo, docetaxel and ADT. The.
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Disusun berdasarkan urutan huruf, berikut arti kosakata Bahasa Jawa Tegal dengan awalan huruf a: apuh [apuh] v diperas sampai kering dan airnya tuntas. Meres kumbahane sing --,si. Memeras cucian hingga kering airnya. apura [apura], ampura [ampura] n maaf; ampun; pangapura [paŋapura] n maaf; ampunan. Njaluk - minta maaf.
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