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The present invention discloses a method for synthesizing cefotaxime sodium, and said method includes the following steps: placing 7-amino cephaloalkyl acid (7-ACA) and benzothiazol active ester (MEAM) in organic solvent, using triethylamine as condensation agent, under the catalysis of phase transfer catalyst making them produce condensation reaction to obtain cefotaxime acid, and making the.
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A population pharmacokinetic model was developed to describe cefotaxime pharmacokinetics and associated variability in adult ICU patients. The estimated creatinine clearance partly explained the IIV in cefotaxime clearance. However, the remaining unexplained IIV is high and suggests a need for dose individualisation using therapeutic drug.
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Abstract. Cefotaxime is a new 'third generation' semisynthetic cephalosporin administered intravenously or intramuscularly. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally more active against Gram-negative bacteria than the 'first' and 'second generation' cephalosporins.
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Cefotaxime | C16H17N5O7S2 | CID 5742673 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities.
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It does not have activity against Pseudomonas aeruginosa. Cefotaxime works by inhibiting bacterial cell wall biosynthesis. A positive feature of cefotaxime is that it display a resistance to penicillinases and is useful to treat infections that are resistant to penicillin derivatives. Mechanism of action.
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Crystalline sodium salt of cefotaxime is separated by filtration, washed with acetone and dried overnight in a vacuum drying chamber at 40°. Yield: 36.6 g; Content of the sodium salt of cefotaxime: 95.9%; Water content: 3.8%. EXAMPLE 3 Production of cefotaxime. 228.3 g of 7-ACA are suspended in 720 ml of acetone.
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Funding from French Government as part of the France Health Innovation Plan 2030 operated by Bpifrance PARIS, Feb. 1, 2024 /PRNewswire/ -- Vivet Therapeutics ("Vivet"), a clinical stage biotech company developing novel and long-lasting gene therapies for rare inherited metabolic disorders, announces the financing of EUR 4.9 million received from the French government to advance the development.
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Cefotaxime. Cefotaxime is an antibiotic used to treat a number of bacterial infections in human, other animals and plant tissue culture. [3] Specifically in humans it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis. [3]
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U.S. Patent No. 4,767,852 discloses a process for the preparation of known 2-oxyiminoacetamido-3-cephem-4-carboxylic acid derivatives, including cefotaxime and ceftriaxone, by acylating 7-amino-3-cephem-4-carboxylic acid derivatives already substituted at the 3-position with 2-mercaptobenzothiazolyl- (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate of formula (III), the latter being often.
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Cefotaxime is a medication used to manage and treat cervicitis/urethritis and pneumonia. Cefotaxime is a beta-lactam antibiotic classified as a third-generation cephalosporin. Its broad-spectrum antibacterial activity is useful in treating the susceptible strains of bacteria affecting the lower respiratory tract, genito-urinary tract, central nervous system, intra-abdominal infections, bone.
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A process for the production of 7-[2-(2-amino-4-thiazolyl)-2-syn-methoxyimino-acetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid (Cefotaxime) in aqueous isopropyl alcohol is provided. The synthesis provides the product in greater than 99 % HPLC purity.
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US patent 4,152,432 discloses the process for the preparation of cefotaxime sodium of formula (I), which involves treating the cefotaxime acid in aqueous solvent such as methanol, ethanol or acetone in the presence of base and sodium ions to give cefotaxime sodium. US patent 5,831,086 describes the process for the preparation of sodium cefotaxime.